Cldn16-KO

品系全名

C57BL/6JSmoc-Cldn16^em1Smoc

目录号

NM-KO-200632

品系状态

胚胎冻存

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基因信息

基因名
Cldn16

基因曾用名

PCLN1， claudin-16

NCBI ID

MGI ID

Ensembl ID

ENSMUSG00000038148

人类同源基因

CLDN16

人类同源基因关联疾病

低镁血症、高钙尿症

品系描述

敲除Cldn16基因exon 2，建立Cldn16基因敲除小鼠模型。

应用领域：Sertoli-Sertoli细胞连接动力学和细胞连接组织相关研究

疾病预测

肾性低镁血症 3
Renal Hypomagnesemia 3

近似模型的表型

参考文献

Will C, Breiderhoff T, Thumfart J, Stuiver M, Kopplin K, Sommer K, Gunzel D, Querfeld U, Meij IC, Shan Q, Bleich M, Willnow TE, Muller D, Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am J Physiol Renal Physiol. 2010 May;298(5):F1152-61

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[ DB ] INIT mysql
[ BEHAVIOR ] Run cmf\behavior\InitHookBehavior @app_init [ RunTime:0.017409s ]
[ LANG ] /data/wwwroot/www.modelorg.com/simplewind/thinkphp/lang/zh-cn.php
[ ROUTE ] array ( 'type' => 'module', 'module' => array ( 0 => 'portal', 1 => 'Article', 2 => 'index', ), 'convert' => false, )
[ HEADER ] array ( 'x5-uuid' => '7880494e08e499947b5d28352f630a77', 'x-real-ip' => '107.158.248.138', 'eagleeye-rpcid' => '0.1', 'cookie' => 'think_var=ko-kr; PHPSESSID=u8eiii6hb513q3pohkb5r1e90h; acw_tc=781bad0a16597176693792116e531dd06bf739c54aa58cdd7366a62595ffc1', 'accept-encoding' => 'gzip', 'accept' => '*/*', 'eagleeye-traceid' => '781bad3616597192109695608e2b1c', 'x-forwarded-cluster' => 'waf,', 'x-forwarded-proto' => 'https', 'x-forwarded-for' => '107.158.248.138', 'wl-proxy-client-ip' => '107.158.248.138', 'web-server-type' => 'nginx', 'x-client-ip' => '107.158.248.138', 'x-true-ip' => '107.158.248.138', 'user-agent' => 'Mozilla/5.0 (Linux; Android 7.0;) AppleWebKit/537.36 (KHTML, like Gecko) Mobile Safari/537.36 (compatible; PetalBot;+https://webmaster.petalsearch.com/site/petalbot)', 'host' => 'www.modelorg.com', 'content-length' => '', 'content-type' => '', )
[ PARAM ] array ( 'id' => '10082', 'post_type' => '3', 'cid' => '50', )
[ LANG ] /data/wwwroot/www.modelorg.com/public/../simplewind/cmf/lang/zh-cn.php
[ LANG ] /data/wwwroot/www.modelorg.com/public/../app/admin/lang/zh-cn/common.php
[ LANG ] /data/wwwroot/www.modelorg.com/public/../app/portal/lang/zh-cn/common.php
[ BEHAVIOR ] Run cmf\behavior\LangBehavior @app_begin [ RunTime:0.000171s ]
[ LANG ] /data/wwwroot/www.modelorg.com/public/../app/portal/lang/zh-cn.php
[ LANG ] /data/wwwroot/www.modelorg.com/public/../app/portal/lang/zh-cn/home.php
[ BEHAVIOR ] Run cmf\behavior\HomeLangBehavior @home_init [ RunTime:0.000102s ]
[ SESSION ] INIT array ( 'id' => '', 'var_session_id' => '', 'prefix' => 'sess-cn', 'type' => 'redis', 'auto_start' => true, 'host' => '172.24.24.205', )
[ CACHE ] INIT Redis
[ RUN ] app\portal\controller\ArticleController->index[ /data/wwwroot/www.modelorg.com/app/portal/controller/ArticleController.php ]
[ VIEW ] themes/mustang/portal/micedetail.html [ array ( 0 => 'site_info', 1 => 'is_login', 2 => 'app_version', 3 => 'cart', 4 => 'cart_total', 5 => 'lang', 6 => 'masterNavId', 7 => 'footerNavId', 8 => 'langList', 9 => 'langCurrent', 10 => 'category', 11 => 'page_type', 12 => 'post_type', 13 => 'article', 14 => 'prev_article', 15 => 'next_article', 16 => 'side_menu', 17 => 'categoryTree', 18 => 'theme_vars', 19 => 'theme_widgets', ) ]
[ LANG ] /data/wwwroot/www.modelorg.com/public/plugins/sy_guestbook/lang/zh-cn.php
[ VIEW ] /data/wwwroot/www.modelorg.com/public/plugins/sy_guestbook/view/css.html [ array ( 0 => 'site_info', 1 => 'is_login', 2 => 'app_version', 3 => 'cart', 4 => 'cart_total', 5 => 'lang', 6 => 'masterNavId', 7 => 'footerNavId', 8 => 'langList', 9 => 'langCurrent', ) ]
[ BEHAVIOR ] Run plugins\sy_guestbook\SyGuestbookPlugin @before_head_end [ RunTime:0.008817s ]
[ RUN ] app\portal\api\ArticleApi->dictList[ /data/wwwroot/www.modelorg.com/app/portal/api/ArticleApi.php ]
[ LANG ] /data/wwwroot/www.modelorg.com/public/plugins/sy_guestbook/lang/zh-cn.php
[ VIEW ] /data/wwwroot/www.modelorg.com/public/plugins/sy_guestbook/view/js.html [ array ( 0 => 'site_info', 1 => 'is_login', 2 => 'app_version', 3 => 'cart', 4 => 'cart_total', 5 => 'lang', 6 => 'masterNavId', 7 => 'footerNavId', 8 => 'langList', 9 => 'langCurrent', ) ]
[ BEHAVIOR ] Run plugins\sy_guestbook\SyGuestbookPlugin @before_body_end [ RunTime:0.000444s ]

1.029773s

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